GrippeEspagneV1, Main, Exploration, bibRecord, 000108

Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit.

Identifieur interne : 000108 ( Main/Exploration ); précédent : 000107; suivant : 000109

Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit.

Auteurs : F. Álvarez-Lerma [Espagne] ; J. Marín-Corral [Espagne] ; C. Vilà [Espagne] ; J R Masclans [Espagne] ; I M Loeches [Irlande (pays)] ; S. Barbadillo [Espagne] ; F J González De Molina [Espagne] ; A. Rodríguez [Espagne]

Source :

The Journal of hospital infection [ 1532-2939 ] ; 2017.

RBID : pubmed:28153560

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de survie (MeSH), Espagne (MeSH), Femelle (MeSH), Grippe humaine (anatomopathologie), Grippe humaine (mortalité), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains (MeSH), Hôpitaux (MeSH), Infection croisée (anatomopathologie), Infection croisée (mortalité), Infection croisée (virologie), Infection croisée (épidémiologie), Jeune adulte (MeSH), Mâle (MeSH), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Unités de soins intensifs (MeSH), Études de cohortes (MeSH).
MESH :
- anatomopathologie : Grippe humaine, Infection croisée.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- mortalité : Grippe humaine, Infection croisée.
- virologie : Grippe humaine, Infection croisée.
- épidémiologie : Grippe humaine, Infection croisée.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de survie, Espagne, Femelle, Humains, Hôpitaux, Jeune adulte, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Unités de soins intensifs, Études de cohortes.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Cohort Studies (MeSH), Cross Infection (epidemiology), Cross Infection (mortality), Cross Infection (pathology), Cross Infection (virology), Female (MeSH), Hospitals (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (epidemiology), Influenza, Human (mortality), Influenza, Human (pathology), Influenza, Human (virology), Intensive Care Units (MeSH), Male (MeSH), Middle Aged (MeSH), Spain (MeSH), Survival Analysis (MeSH), Young Adult (MeSH).
MESH :
- epidemiology : Cross Infection, Influenza, Human.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- mortality : Cross Infection, Influenza, Human.
- pathology : Cross Infection, Influenza, Human.
- virology : Cross Infection, Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Hospitals, Humans, Intensive Care Units, Male, Middle Aged, Spain, Survival Analysis, Young Adult.

Abstract

BACKGROUND

Influenza A (H1N1)pdm09 virus infection acquired in the hospital and in critically ill patients admitted to the intensive care unit (ICU) has been poorly characterized.

AIM

To assess the clinical impact of hospital-acquired infection with influenza A (H1N1)pdm09 virus in critically ill patients.

METHODS

Analysis of a prospective database of the Spanish registry (2009-2015) of patients with severe influenza A admitted to the ICU. Infection was defined as hospital-acquired when diagnosis and starting of treatment occurred from the seventh day of hospital stay with no suspicion on hospital admission, and community-acquired when diagnosis was established within the first 48 h of admission.

FINDINGS

Of 2421 patients with influenza A (H1N1)pdm09 infection, 224 (9.3%) were classified as hospital-acquired and 1103 (45.6%) as community-acquired (remaining cases unclassified). Intra-ICU mortality was higher in the hospital-acquired group (32.9% vs 18.8%, P < 0.001). Independent factors associated with mortality were hospital-acquired influenza A (H1N1)pdm09 infection (odds ratio: 1.63; 95% confidence interval: 1.37-1.99), APACHE II score on ICU admission (1.09; 1.06-1.11), underlying haematological disease (3.19; 1.78-5.73), and need of extrarenal depuration techniques (4.20; 2.61-6.77) and mechanical ventilation (4.34; 2.62-7.21).

CONCLUSION

Influenza A (H1N1)pdm09 infection acquired in the hospital is an independent factor for death in critically ill patients admitted to the ICU.

DOI: 10.1016/j.jhin.2016.12.017
PubMed: 28153560

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00102
to stream Main, to step Curation: 000102

Le document en format XML

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<author><name sortKey="Gonzalez De Molina, F J" sort="Gonzalez De Molina, F J" uniqKey="Gonzalez De Molina F" first="F J" last="González De Molina">F J González De Molina</name>
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<author><name sortKey="Gonzalez De Molina, F J" sort="Gonzalez De Molina, F J" uniqKey="Gonzalez De Molina F" first="F J" last="González De Molina">F J González De Molina</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Cohort Studies (MeSH)</term>
<term>Cross Infection (epidemiology)</term>
<term>Cross Infection (mortality)</term>
<term>Cross Infection (pathology)</term>
<term>Cross Infection (virology)</term>
<term>Female (MeSH)</term>
<term>Hospitals (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (mortality)</term>
<term>Influenza, Human (pathology)</term>
<term>Influenza, Human (virology)</term>
<term>Intensive Care Units (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Spain (MeSH)</term>
<term>Survival Analysis (MeSH)</term>
<term>Young Adult (MeSH)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de survie (MeSH)</term>
<term>Espagne (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (anatomopathologie)</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Hôpitaux (MeSH)</term>
<term>Infection croisée (anatomopathologie)</term>
<term>Infection croisée (mortalité)</term>
<term>Infection croisée (virologie)</term>
<term>Infection croisée (épidémiologie)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Unités de soins intensifs (MeSH)</term>
<term>Études de cohortes (MeSH)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Infection croisée</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cross Infection</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cross Infection</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term>
<term>Infection croisée</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cross Infection</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Infection croisée</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cross Infection</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Infection croisée</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Hospitals</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Spain</term>
<term>Survival Analysis</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Espagne</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hôpitaux</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Unités de soins intensifs</term>
<term>Études de cohortes</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Influenza A (H1N1)pdm09 virus infection acquired in the hospital and in critically ill patients admitted to the intensive care unit (ICU) has been poorly characterized.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>AIM</b>
</p>
<p>To assess the clinical impact of hospital-acquired infection with influenza A (H1N1)pdm09 virus in critically ill patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Analysis of a prospective database of the Spanish registry (2009-2015) of patients with severe influenza A admitted to the ICU. Infection was defined as hospital-acquired when diagnosis and starting of treatment occurred from the seventh day of hospital stay with no suspicion on hospital admission, and community-acquired when diagnosis was established within the first 48 h of admission.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>FINDINGS</b>
</p>
<p>Of 2421 patients with influenza A (H1N1)pdm09 infection, 224 (9.3%) were classified as hospital-acquired and 1103 (45.6%) as community-acquired (remaining cases unclassified). Intra-ICU mortality was higher in the hospital-acquired group (32.9% vs 18.8%, P < 0.001). Independent factors associated with mortality were hospital-acquired influenza A (H1N1)pdm09 infection (odds ratio: 1.63; 95% confidence interval: 1.37-1.99), APACHE II score on ICU admission (1.09; 1.06-1.11), underlying haematological disease (3.19; 1.78-5.73), and need of extrarenal depuration techniques (4.20; 2.61-6.77) and mechanical ventilation (4.34; 2.62-7.21).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Influenza A (H1N1)pdm09 infection acquired in the hospital is an independent factor for death in critically ill patients admitted to the ICU.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2017</Year>
<Month>03</Month>
<Day>01</Day>
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<Month>12</Month>
<Day>24</Day>
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<JournalIssue CitedMedium="Internet"><Volume>95</Volume>
<Issue>2</Issue>
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<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of hospital infection</Title>
<ISOAbbreviation>J. Hosp. Infect.</ISOAbbreviation>
</Journal>
<ArticleTitle>Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit.</ArticleTitle>
<Pagination><MedlinePgn>200-206</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0195-6701(16)30588-6</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhin.2016.12.017</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Influenza A (H1N1)pdm09 virus infection acquired in the hospital and in critically ill patients admitted to the intensive care unit (ICU) has been poorly characterized.</AbstractText>
<AbstractText Label="AIM" NlmCategory="OBJECTIVE">To assess the clinical impact of hospital-acquired infection with influenza A (H1N1)pdm09 virus in critically ill patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Analysis of a prospective database of the Spanish registry (2009-2015) of patients with severe influenza A admitted to the ICU. Infection was defined as hospital-acquired when diagnosis and starting of treatment occurred from the seventh day of hospital stay with no suspicion on hospital admission, and community-acquired when diagnosis was established within the first 48 h of admission.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">Of 2421 patients with influenza A (H1N1)pdm09 infection, 224 (9.3%) were classified as hospital-acquired and 1103 (45.6%) as community-acquired (remaining cases unclassified). Intra-ICU mortality was higher in the hospital-acquired group (32.9% vs 18.8%, P < 0.001). Independent factors associated with mortality were hospital-acquired influenza A (H1N1)pdm09 infection (odds ratio: 1.63; 95% confidence interval: 1.37-1.99), APACHE II score on ICU admission (1.09; 1.06-1.11), underlying haematological disease (3.19; 1.78-5.73), and need of extrarenal depuration techniques (4.20; 2.61-6.77) and mechanical ventilation (4.34; 2.62-7.21).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Influenza A (H1N1)pdm09 infection acquired in the hospital is an independent factor for death in critically ill patients admitted to the ICU.</AbstractText>
<CopyrightInformation>Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Álvarez-Lerma</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital del Mar, Barcelona, Spain; Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marín-Corral</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital del Mar, Barcelona, Spain; Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. Electronic address: jmarincorral@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vilà</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital del Mar, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Masclans</LastName>
<ForeName>J R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital del Mar, Barcelona, Spain; Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Universitat Pompeu Fabra, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loeches</LastName>
<ForeName>I M</ForeName>
<Initials>IM</Initials>
<AffiliationInfo><Affiliation>Service of Intensive Care Medicine, St James's Hospital, Dublin, Ireland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barbadillo</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital General de Catalunya, Sant Cugat del Vallés, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>González de Molina</LastName>
<ForeName>F J</ForeName>
<Initials>FJ</Initials>
<AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rodríguez</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital Universitari Joan XXIII, Tarragona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>H1N1 GETGAG/SEMICYUC Study Group</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>12</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Hosp Infect</MedlineTA>
<NlmUniqueID>8007166</NlmUniqueID>
<ISSNLinking>0195-6701</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003428" MajorTopicYN="N">Cross Infection</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006761" MajorTopicYN="N">Hospitals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Community-acquired infections</Keyword>
<Keyword MajorTopicYN="Y">Critically ill</Keyword>
<Keyword MajorTopicYN="Y">H1N1 subtype</Keyword>
<Keyword MajorTopicYN="Y">Infuenza A virus</Keyword>
<Keyword MajorTopicYN="Y">Mortality</Keyword>
<Keyword MajorTopicYN="Y">Nosocomial infection</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>11</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>12</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>2</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>3</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>2</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28153560</ArticleId>
<ArticleId IdType="pii">S0195-6701(16)30588-6</ArticleId>
<ArticleId IdType="doi">10.1016/j.jhin.2016.12.017</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
<li>Irlande (pays)</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
<orgName><li>Université Pompeu Fabra</li>
<li>Université autonome de Barcelone</li>
</orgName>
</list>
<tree><country name="Espagne"><region name="Catalogne"><name sortKey="Alvarez Lerma, F" sort="Alvarez Lerma, F" uniqKey="Alvarez Lerma F" first="F" last="Álvarez-Lerma">F. Álvarez-Lerma</name>
</region>
<name sortKey="Barbadillo, S" sort="Barbadillo, S" uniqKey="Barbadillo S" first="S" last="Barbadillo">S. Barbadillo</name>
<name sortKey="Gonzalez De Molina, F J" sort="Gonzalez De Molina, F J" uniqKey="Gonzalez De Molina F" first="F J" last="González De Molina">F J González De Molina</name>
<name sortKey="Marin Corral, J" sort="Marin Corral, J" uniqKey="Marin Corral J" first="J" last="Marín-Corral">J. Marín-Corral</name>
<name sortKey="Masclans, J R" sort="Masclans, J R" uniqKey="Masclans J" first="J R" last="Masclans">J R Masclans</name>
<name sortKey="Rodriguez, A" sort="Rodriguez, A" uniqKey="Rodriguez A" first="A" last="Rodríguez">A. Rodríguez</name>
<name sortKey="Vila, C" sort="Vila, C" uniqKey="Vila C" first="C" last="Vilà">C. Vilà</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Loeches, I M" sort="Loeches, I M" uniqKey="Loeches I" first="I M" last="Loeches">I M Loeches</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit.

Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit.

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